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Wiith 할머니 요리

Clinically Proven


Cholesterol Postbiotics

BBR4401® is Korea's second postbiotics approved by KFDA. 

BBR4401® hydrolyzes conjugated bile, promoting de novo synthesis of bile acids from cholesterol, and BBR 4401 interacts with cholesterol physiochemically, resulting in the excretion of cholesterol into feces.

Through the study, BBR4401®  showed that defecation strain, distension, and runny feces significantly improved after a 12-week prescription of BBR 4401 in the low- and high-dose groups.

Lower your cholesterol and improve gut health with BBR4401®

​BBR4401 Mechanism of action


Hydrolysis of Conjugated Bile:


BBR4401® has the ability to break down or hydrolyze these conjugated bile acids. By doing so, it promotes the body's response to produce more bile acids from cholesterol. This increase in bile acid synthesis prompts the liver to utilize more cholesterol in its production process. As a result, the liver pulls LDL cholesterol from the bloodstream to create the necessary cholesterol supply for bile acid synthesis. This effectively reduces the levels of LDL cholesterol circulating in the blood.

Physiochemical Interaction with Cholesterol:


BBR4401® also has a physiochemical interaction with cholesterol. This interaction alters the way cholesterol is handled in the body. This mechanism might involve BBR4401® binding to cholesterol molecules, which changes their properties. As a result of this interaction, cholesterol is more likely to be excreted from the body through the feces.

When cholesterol is excreted through the feces, the body experiences a reduction in its overall cholesterol levels, particularly LDL cholesterol. This is significant because LDL cholesterol is often referred to as "bad" cholesterol due to its role in contributing to the buildup of plaques in arteries, which can lead to cardiovascular diseases.

A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Cholesterol-Lowering Effect of BBR 4401 in Adults with Moderate Hypercholesterolemia (Fermentation Journal, 2023)

What is LDL & HDL Cholesterol?

HDL Cholesterol (Good Cholesterol):


HDL cholesterol is often called "good" cholesterol because it plays a protective role in cardiovascular health. HDL helps remove excess cholesterol from the bloodstream and transport it back to the liver for elimination. This process can prevent the buildup of plaque in arteries and reduce the risk of heart disease. Higher levels of HDL are generally associated with better heart health.

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Healthy and unhealthy food background from fruits and vegetables vs fast food, sweets and

LDL Cholesterol (Bad Cholesterol):

LDL cholesterol is often referred to as "bad" cholesterol because high levels can contribute to plaque buildup in your arteries, leading to atherosclerosis (hardening and narrowing of arteries). This can increase the risk of heart disease, heart attacks, and strokes. LDL carries cholesterol from the liver to cells throughout your body, but if there's an excess of LDL, it can deposit cholesterol in artery walls, leading to the aforementioned issues.

Clinical on Circulatory System

LDL Cholesterol Change



LDL-cholesterol was significantly decreased compared to the placebo group in

the low-dose(10B cells/day) and high-dose(100B cells/day) groups at weeks 12

ApoB*(apolipoprotein B) Change

*A protein that plays a central role in the transportation of lipids (fats) in the bloodstream. ApoB is measured in clinical settings as ApoB levels can provide valuable information about a person's risk for cardiovascular diseases. Elevated levels of ApoB are associated with an increased risk of atherosclerosis and heart disease.

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ApoB showed a significant decrease in both low-dose(10B cells/day) and high-dose(100B cells/day) groups at weeks 12

Clinical on Gut Health, Bowel Habit

Defecation Strain

(5 Point Likert Scale)

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(5 Point Likert Scale)

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Runny Feces

(5 Point Likert Scale)

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Defecation strain, distension, and runny feces significantly improved after  a 12-week prescription of

BBR 4401 in both low-dose(10B cells/day) and high-dose(100B cells/day) groups at weeks 12

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