RHT3201™ is Korea's first postbiotics approved by KFDA.
The goal of RHT3201™, to maintain a balanced immunological response in human bodies, is essential as excessive immunological responses can cause hypersensitivity reactions.
Through several studies, RHT3201™ has shown significant effects on the production of cytokines and helps to modulate the balanced immune response between Th1 and Th2. These immunomodulatory effects lead to the suppression of hypersensitivity reactions.
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What is Hypersensitivity Reaction?
Hypersensitivity reactions are undesirable overreactions produced by the normal immune system, such as allergies and autoimmunity.
They can occur when immune functions work excessively against a foreign substance entering the body, resulting in an immune balance breakdown.
Overall Allergy Reaction
Under normal circumstances, the body maintains an immune balance.
When there are hypersensitivity symptoms like allergy and asthma, this means that there is an imbalance in the immune cells and that Th2 cells are working too hard, leading to a hypersensitivity reaction.*
* Development of Tyndallized Lactobacillus rhamnosus IDCC 3201 with Immunomodulation: Optimization, Validation, and in vitro Evaluation. KSBB Journal, 32(4), 271-278.
By subgroup analysis at week 12 in subjects with AD for ≥50 months, the changes in ECP levels, eosinophil count, and IL-31 levels were significantly different between the two groups.
The mean ECP level, eosinophil count, and IL-31 levels were decreased in the RHT3201 group; this change was statistically significant between the two groups
SCORAD* Score Evaluation
*SCORing of Atopic Dermatitis(SCORAD)
In subgroup analysis at week 12 among subjects with AD for ≥50 months, the difference in objective SCORAD score was statistically different between groups The difference in the reduction of the extent of disease was significantly greater in the RHT3201-treated group than in the placebo group.
Change of SCORAD objective scores (objective total score, extent of disease score, and intensity of disease score) from weeks 0 to 12 in subjects with atopic dermatitis for over 50 months duration
Total serum IgE concentrations &
Measurement of cytokines in draining lymph node cells
Compared with the control group, total serum IgE concentrations were significantly down-regulated, and All RHT3201-fed groups had significantly smaller amounts of the Th2 cytokine IL-4 than the control group.
As the input of RHT3201™ increased, the result of total serum IgE and cytokines decreased.
RHT3201™ can broaden your probiotic options.
RHT3201™ provides formulation flexibility of postbiotics,
with none of the stability or manufacturing concerns.
Until now, you might have only been able to rely on a few applications compatible
when working with the probiotic category.
RHT3201™ is your other option in those delivery formats that require really high heat or water activity.